PGAD stance for persistent genital arousal disorder. It’s a neurological disorder that causes patients to have Buzzy and/or painful sensation in the genitals. Please do not confuse any of this with pleasure. A patient asked me if this dysfunction has anything to do with estrogen and after reading many articles, I am coming up with a conclusion that estrogen does playing important role, because when estrogen is low, the repair in the growth of the nerve is low and patients suffer more with depres