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உத்தரப் பிரதேசம் மாநிலத்தில் தண்டவாளத்தை கடக்க மறுத்த ஆடுகள்... ரயில் மோதி 30-க்கும் மேற்பட்டவை பலி!
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உத்தரப் பிரதேசம் மாநிலத்தில் தண்டவாளத்தை கடக்க மறுத்த ஆடுகள்... ரயில் மோதி 30-க்கும் மேற்பட்டவை பலி!
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GABA!!! Two big distinctions here— positive allosteric modulators (benzos) vs direct agonists (anesthetics like propofol or alfaxalone). Disinhibitions occurs because downstream neurons are not receiving inhibitory signals anymore (because that presynaptic neuron is inhibited by our drug while normally it releases GABA to calm downstream neurons). neuropharm is so juicy. #fyp #gaba #vetmed
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Administering low-dose intravenous ketamine transforms multimodal general anesthesia by targeting central pain pathways before surgical stimulation begins. Ketamine functions as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, dampening dorsal horn wind-up and preventing acute central sensitization (Peltoniemi et al., 2016). When combined synergistically with gamma-aminobutyric acid (GABA) receptor agonists like propofol, it produces reliable hypnotic depth and somatic analgesia
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