Wilson Map. Wilson is a city and the county seat of Wilson County in the Coastal Plain region of the U.S. state of North Carolina. The 17th largest city in the state, Wilson had a population of 50,652 according to the 2007 estimate. Wilson is located at 35°43?52?N 77°55?25?W / 35.73111°N 77.92361°W / 35.73111; -77.92361 (35.731093, -77.923509).