This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

The greatly diverged chicken and zebrafish insulin promoters lack mammalian A boxes ... regulatory element may be influential in insulin expression, perhaps playing a role in energy homeostasis.

Andrew Teschendorff, Professor at the Chinese Academy of Sciences, is developing computational systems-biological tools to ...

While the last decade has brought considerable progress for patients with DMD, substantial unmet need remains. Several ...

Beam Therapeutics Inc. (Nasdaq: BEAM), a biotechnology company developing precision genetic medicines through base editing, today announced the company will encore data from the BEACON Phase 1/2 ...

"First-generation gene therapies for DMD use very high doses of naturally occurring capsids that primarily target the liver, and promoters that are more active in skeletal muscle than heart in ...

Biology has yet to tap into the full benefits of computer simulations, but a new AI foundation model developed by a team of scientists including CMU's Eric Xing hopes to change that.

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

Scientists at UC San Diego find that gene expression is linked to gene mutations and may be caused by them. That could make ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.