The 49ers made Bills quarterback Josh Allen look like John Freaking Elway. Allen completed a whopping 80 percent of his throws during the 49ers 34-24 loss Monday night. They couldn’t pressure him or contest his throws or make him sweat. Embarrassing.

The San Francisco 49ers will take on the Buffalo Bills in the Week 13 edition of NBC's "Sunday Night Football." What to know about the game.

As the 49ers undergo an ambitious roster reshuffle, San Francisco is drawing inspiration from two recent rebuilds from a pair of contending teams. During an exclusive interview with Sports Illustrated’s Albert Breer, 49ers general manager John Lynch ...

There's a reason the 49ers are the favorites against the Buffalo Bills. That's right. Oddsmakers have given the 49ers, who are 5-6, a one-point advantage over the Buffalo Bills. who are 8-3. And not because the 49ers have home-field advantage. Technically ...

The Denver Broncos and Los Angeles Rams both punched their ticket to the playoffs on Sunday and as of right now, those are the only two teams who have clinched a spot. The Broncos actually have a path to clinch the No. 1 overall seed in the AFC this week, but there's only one scenario where that could happen in Week 16:

Colin Cowherd lists his best bets entering Week 11, including the Buffalo Bills over the Tampa Bay Buccaneers, the Seattle Seahawks over the Los Angeles Rams, and the San Francisco 49ers over the Arizona Cardinals. 12 players who could have a December to ...

Josh Allen accounted for four total touchdowns, though two of them came on the same play, as the Bills won their seventh straight game and clinched their fifth straight division title. Allen threw for two TDs and rushed for another, and he also recorded a ...

The Buffalo Bills and Cincinnati Bengals are expected to play in a snow game when they meet on Sunday in Orchard Park.

The Tennessee Titans fell to the San Francisco 49ers in Week 15 action, and here is how Titans Wire graded the team's performance.