In a recent study published in the journal EMBO Reports, researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases (RTKs), ...

The transduction of extracellular signals across the membrane to initiate complex cascades of molecular events regulates numerous vital cellular processes. The molecular basis of ...

Safety analysis of targeted therapy in mRCC: Montenegro experience. A phase 1b dose-escalation study of TRC105 (anti-endoglin antibody) in combination with axitinib in patients with metastatic renal ...

Population pharmacokinetics (popPK) and exposure-response (ER) analyses bridge J-ALEX to the global population with an alectinib (ALC) 600mg bid dosing regimen. This is an ASCO Meeting Abstract from ...