Using technology they developed, UT Southwestern Medical Center researchers have identified a previously unknown role of a certain class of proteins: as regulators of gene activity and RNA processing.

Prevalence of breast cancer across racial, socioeconomic, and regional groups in the US: Analysis of comorbidity distributions using the National Inpatient Sample Database in 2019-2020.

Inherited mutations in the gene BRCA2 significantly increase the risk of carriers to breast and ovarian cancers. BRCA2, a crucial player in the body's DNA repair system, aids in repairing damaged DNA.

How Does Lynparza Work for Ovarian Cancer? Lynparza is a type of medicine known as poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is a certain protein that helps cancer cells survive and grow. It ...

A new study introduces an adaptive therapy approach that could optimize PARP inhibitor maintenance therapy, offering a more personalized and potentially less toxic treatment option for patients.

Some anti-cancer treatments not only target tumor cells but also healthy cells. If their effects on the latter are too strong, their use can become limiting. A team from the University of Geneva ...

Treatment for hormone receptorpositive (HR-positive)/HER2-negative metastatic breast cancer often starts with hormone therapy (tamoxifen or an aromatase inhibitor ...

BRCA genes and PARP operate in complementary repair pathways. So, if a cancer cell already has a faulty BRCA1 or BRCA2 gene, inhibiting the PARP protein – which normally helps repair DNA – overwhelms ...