Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
In eukaryotic cells, DNA polymerase (Pol) ε and Pol δ synthesize the leading and lagging strands, respectively 1,2. These enzymes work in the 5′-to-3′ direction, resulting in continuous replication of ...
DNA double-strand breaks (DSBs) represent a critical form of damage in which both strands of the DNA helix are severed. If left unrepaired or misrepaired, DSBs can lead to chromosomal translocations, ...
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