Explore the role of transcription factor biology in drug discovery and how it impacts our understanding of disease mechanisms ...

The mammalian liver has an extraordinary regenerative capacity, capable of fully restoring its mass and function after injury or partial resection. A study led by researchers at the University of ...

Transcription factors are the most powerful genes in our body. They are master regulators and have been implicated in our biggest diseases, even aging itself. Yet, many in the pharmaceutical industry ...

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature ...

Peer-reviewed discovery platform and data in PNAS show that single transcription factor modulation reverses aging-associated gene expression and restores healthy cellular and tissue function in models ...

A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.

Researchers from Northwestern University have stumbled upon a previously unobserved function of a protein found in the cell nuclei of all flora and fauna. In addition to exporting materials out of the ...

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

The morning glory transcription factor EPH1 binds in the vicinity of genes associated with programmed cell death after a certain time after flowering and activates the expression of these genes. The ...

A newly discovered code within DNA – coined “spatial grammar” – holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding, identified by researchers at ...