John Lynch and Kyle Shanahan get along well and trust each other. That much was obvious as recently as a week ago, when Shanahan asked Lynch to speak to the team the night before 49ers' game against ...

SANTA CLARA, Calif. (AP) — The San Francisco 49ers' last road trip of the regular season was a successful one. The Niners clinched a playoff spot while in their hotel on Sunday, beat the Indianapolis ...

Monday, 8:15 p.m. EST, ESPN. BetMGM NFL odds: 49ers by 6. Against the spread: 49ers 9-5; Colts 8-6. Series record: Colts lead 27-18. Last meeting: Colts beat 49ers 30-18 on Oct. 24, 2021, in Santa ...

The Indianapolis Colts' defense had zero answers on Monday night for the San Francisco 49ers' offense. Brock Purdy was 25-of-34 passing for 295 yards with five touchdowns to one interception.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

The Indianapolis Colts are reeling again after suffering a fifth-straight loss, this time to the San Francisco 49ers. What was a brilliant game from Philip Rivers in just his second start since ...