Two rare mutations in the APOE gene ― APOE ε4 (R251G) and APOE ε3 (V236E) ― dramatically reduce the risk of developing Alzheimer's disease (AD), results of a large genetic association study show. APOE ...

The risk for future incident mild cognitive impairment or dementia in older women was elevated with higher levels of plasma phosphorylated tau 217, according to data published in JAMA Network Open.“Ou ...

Voyager Therapeutics has hit pause on a preclinical Alzheimer’s disease program just eight months after unveiling the asset. The neurology biotech announced back in July 2025 that it was adding a new ...

ApoE research is not just about its three main alleles. You may have heard the words Christchurch and Jacksonville in connection with ApoE, but did you know that well over 100 variants have been ...

Advanced proteomics and AI reveal blood protein changes, offering insights into early Alzheimer's detection and differentiation from mild cognitive impairment.

Using the largest sample of super-agers to date, scientists have found convincing evidence that supports what many of us have suspected: Longevity isn’t just about healthy lifestyle choices, but also ...

See Part 5 and Part 6 of this series. Most amyloid fibrils in the human body are toxic, but a select few perform important functions. What sets them apart? At the Society for Neuroscience annual ...

VIENNA, Austria — Association of the apolipoprotein E ε4 (APOE) allele and greatly elevated risk of developing Alzheimer's disease emerged 2 decades ago. But a recent study indicates that the level of ...

Please provide your email address to receive an email when new articles are posted on . The APOE e4 allele correlated with earlier clinical and biomarker-related changes of Alzheimer’s disease among ...