Without efforts to address some causes, including alcohol use and metabolic issues, the researchers warn that cases could nearly double by 2050.

Researchers warn that the public, policy makers and even clinicians are not aware of the growing problem of liver cancer.

Liver cancer is still relatively rare in the United States, representing 2.1% of all new cancer diagnoses in 2025. The report estimated that by 2040, U.S. rates of MASLD could more than double, affecting more than 55% of adults.